ABSTRACT
Objectives: To evaluate the role of pentraxin-3 [PTX-3] in determining the presence and severity of coronary atherosclerosis in patients with coronary artery disease [CAD]
Subjects and Methods: Ninety-five patients [77 males and 18 females] who underwent elective coronary angiography were enrolled in this study. Patients with heart failure, renal failure, diabetes and thyroid disease were excluded. The study population was divided into 3 groups: individuals with normal coronary arteries, patients with critical CAD [n = 35] and patients with noncritical CAD [n = 36]. The association of PTX-3 levels with the presence and severity of CAD and the number of involved vessels were analyzed
Results: The mean age was 53.40 +/- 10.25 years. The PTX-3 levels were significantly higher in patients with CAD than without CAD [146.48 +/- 48.52 vs. 109.83 +/- 49.06 pg/ml, p < 0.001]. A statistically significant difference was found among the 3 groups regarding the severity of CAD [165.66 +/- 49.10, 127.83 +/- 40.51 and 109.83 +/- 49.06 pg/ml, p < 0.001, respectively]. The serum PTX-3 levels in normal arteries were 110.4 +/- 48.11 pg/ml, in single-vessel disease 132.35 +/- 32.96 pg/ml, in 2-vessel disease 142.57 +/- 55.88 pg/ml, in 3-vessel disease 156.07 +/- 50.53 pg/ml, and in 3-vessel disease 160.50 +/- 30.41 pg/ml. After adjusting for baseline confounders, older age [OR = 1.107, 95% CI = 1.027-1.193, p = 0.008] and higher PTX-3 levels [OR = 1.017, 95% CI = 1.003-1.032, p = 0.021] were detected as significant predictors for the presence of CAD
Conclusions: Higher PTX-3 levels were associated with the presence of CAD and its increased severity in clinically stable patients. Higher PTX-3 levels may be regarded as a novel diagnostic predictor and may offer therapeutic options in the clinic
Subject(s)
Humans , Male , Female , Middle Aged , Adult , C-Reactive Protein , Coronary Artery Disease , Coronary Angiography , AtherosclerosisABSTRACT
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